Journal: BMJ Open Diabetes Research & Care

Article Title: KGF-2 and FGF-21 poloxamer 407 hydrogel coordinates inflammation and proliferation homeostasis to enhance wound repair of scalded skin in diabetic rats

doi: 10.1136/bmjdrc-2019-001009

Figure Lengend Snippet: Characteristic of thermosensitive hydrogel. (A) Control release profile of FGF-21, KGF-2 and KGF-2/FGF-21 mixtures loaded hydrogel compared with that of corresponding protein in 0.9% saline respectively (n=3). ‘a, b, c’ indicated as significantly different from corresponding protein in 0.9% saline respectively (p<0.01). (B) Gelation of thermosensitive hydrogel. (C) Storage modulus and loss modulus of thermosensitive hydrogel. (D) SEM images of thermosensitive hydrogel (scale bars, 50 µm). (E) Skin wound of GK rat (scales 0.2 cm per square). (F) Wound healing rate. compared with the control group, *p<0.05, **p<0.01, ***p<0.001 (n=7 on day 7, n=6 on day 14, n=6 on day 25, n=3 on day 31). FGF-21, fibroblast growth factor-21; F21–K2, FGF-21 and KGF-2; GK, Goto-Kakizaki; KGF-2, keratinocyte growth factor-2; SEM, scanning electron microscope.

Article Snippet: Sections were photographed with a upright Nikon microscope (ECLPSE 80i, Tokyo, Japan) at 40-fold or 100-fold magnification to view the wound area.

Techniques: Control, Saline, Microscopy

Journal: Materials Today Bio

Article Title: Polydopamine-cladded montmorillonite micro-sheets as therapeutic platform repair the gut mucosal barrier of murine colitis through inhibiting oxidative stress

doi: 10.1016/j.mtbio.2023.100654

Figure Lengend Snippet: Gut distribution of orally administrated PDA/MMT. ( A ) Schematic of ex vivo imaging of gut using IVIS system, and corresponding confocal laser scanning microscope (CLSM) imaging of colon sections. ( B ) The ex vivo imaging of gut of different groups at 0.5, 1.5, 4, and 6 ​h after oral administration, and corresponding CLSM imaging of colon sections. ( C ) fluorescence intensity of colon. ( D ) Relative ROS scavenging viability of PDA/MMT treated with simulated gastric fluid (SGF) for 1 ​h and simulated intestinal fluid (SIF) for 3 ​h.

Article Snippet: Finally, the histological morphology of the colon was observed under a Nikon microscope (Nikon ECLPSE 80i, Japan).

Techniques: Ex Vivo, Imaging, Laser-Scanning Microscopy, Fluorescence

Journal: The Journal of International Medical Research

Article Title: Protective effects of luteolin on nephrotoxicity induced by long-term hyperglycaemia in rats

doi: 10.1177/0300060520903642

Figure Lengend Snippet: Representative renal sections of each group as shown by transmission electron microscopy with different magnifications. Red arrows indicate podocyte foot processes. Yellow arrows indicate the glomerular basement membrane (a: × 3000; b: × 8000; c: × 10,000). LUT: luteolin.

Article Snippet: The positive points were dyed brown and observed using optical microscopy (ECLPSE 80i; Nikon).

Techniques: Transmission Assay, Electron Microscopy, Membrane